Dark-roasted coffee dampens a crucial mechanism in inflammation and induces a pivotal mechanism in oxidative stress defense which has been implicated in a having a role in a number of health conditions and diseases.
Degree of roasting is the main determinant of the effects of coffee on NF-kappaB and EpRE.: "Paur, I., Balstad, T. R., and Blomhoff, R. (2010). Degree of roasting is the main determinant of the effects of coffee on nf-kappab and epre. Free radical biology & medicine, 48(9):1218-1227."
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